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Alzheimer Disease

Company files new drug application for compound to treat Alzheimer disease

Published in Medical Letter on the CDC and FDA, July 10th, 2005

TorreyPines Therapeutics announced that it has filed an investigational new drug (IND) application with the U.S. Food and Drug Administration (FDA) for NGX267, a compound designed to treat Alzheimer disease.

GX267 is a selective cholinergic muscarinic receptor agonist (M1 subtype) with properties suggesting the potential for both symptomatic and disease modification therapy in Alzheimer disease.

The M1 receptor plays an important role in memory and cognitive processing. Its activation has also been linked to decreases in 2 biochemical processes, AB production and tau protein phosphorylation, both of which are involved in the creation of the...

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