Rabies
Rabies virus-neutralizing epitope recognized by human monoclonal antibody
Published in Medical Letter on the CDC and FDA, July 17th, 2005
According to a study from the Netherlands, "Antirabies virus immunoglobulin combined with rabies vaccine protects humans from lethal rabies infections. For cost and safety reasons, replacement of the human or equine polyclonal immunoglobulin is advocated, and the use of rabies virus-specific monoclonal antibodies (MAbs) is recommended."
"We produced two previously described potent rabies virus-neutralizing human MAbs, CR57 and CRJB, in human PER.C6 cells. The two MAbs competed for binding to rabies virus glycoprotein.
"Using CR57 and a set of 15-mer...
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