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Tularemia Vaccine

Intranasal vaccine protects against intranasal Francisella infection

Published in Medical Letter on the CDC and FDA, July 17th, 2005

Intranasal vaccination induces protective immunity against intranasal infection with virulent Francisella tularensis biovar A.

"The inhalation of Francisella tularensis biovar A causes pneumonic tularemia associated with high morbidity and mortality rates in humans. Exposure to F. tularensis usually occurs by accident, but there is increasing awareness that F. tularensis may be deliberately released in an act of bioterrorism or war. The development of a vaccine against pneumonic tularemia has been limited by a lack of information regarding the mechanisms required to protect against this disease," researchers in the United States...

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