Gynecology
Precolposcopic procedures do not change cervical tissue gene profiles
Published in Medical Letter on the CDC and FDA, July 17th, 2005
"Among tumor sites, cervical cancer offers an ideal model for investigating differences in gene expression associated with transitions from normal to precancer and invasion to cancer," scientists writing in the journal Diagnostic Molecular Pathology report.
"To evaluate the validity of assessing gene expression in cervical tissues acquired in a clinical setting, we investigated whether standard procedures, namely the application of acetic acid and/or Lugol's iodine, employed for the visualization of colposcopically directed biopsies, altered patterns in oligonucleotide...
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