Mycobacterium Tuberculosis
Transmembrane TNF provides acute control of M. tuberculosis infection
Published in Medical Letter on the CDC and FDA, July 24th, 2005
"TNF is critical for immunity against Mycobacterium tuberculosis infection; however, the relative contributions of the soluble and transmembrane forms of TNF in this immunity are unknown. Using transmembrane TNF (memTNF) mice, which express only the transmembrane form of TNF, we have addressed this question," researchers in the United States report.
"Wild-type (WT), TNF-/-, and memTNF mice were infected with M. tuberculosis by aerosol. TNF-/-mice developed overwhelming infection with extensive pulmonary necrosis and died after only 33 days," said...
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