Necatoriasis Vaccine
Hookworm calreticulin is potential vaccine candidate for necatoriasis
Published in Medical Letter on the CDC and FDA, July 24th, 2005
According to recent research from England, "A vaccine against the human hookworm Necator americanus is urgently required to reduce hookworm-induced morbidity in endemic areas.
"In the present study, recombinant hookworm calreticulin, a nominated vaccine candidate, has been tested in mice. Mice given calreticulin had 43-49% fewer worms in their lungs, compared to non-vaccinated controls, following challenge infection with infective hookworm larvae. These levels of protection were achieved in the absence of adjuvant following intraperitoneal administration of three doses of...
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