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Pseudomonas Aeruginosa

Substance P regulates NK cell IFN-gamma production/resist to P. aeruginosa

Published in Medical Letter on the CDC and FDA, July 24th, 2005

Substance P regulates natural killer cell interferon-gamma production and resistance to Pseudomonas aeruginosa infection.

According to recent research from the United States, "Studies have shown that after Pseudomonas aeruginosa (P. aeruginosa) corneal infection, BALB/c mice that are capable of resolving the disease, locally produce IFN-gamma. As T cells are not detected in the infected cornea of these mice, antibody depletion was used to test whether NK cells produce the cytokine."

"After depletion," the authors said, "decreased corneal IFN-gamma mRNA and increased disease severity, bacterial load, and PMN infiltrate resulted....

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