Sepsis Therapy
Dendritic cells encoding IL-10 used to treat sepsis
Published in Medical Letter on the CDC and FDA, July 24th, 2005
According to a study from the United States, "Control of dendritic cell (DC) function is critical for strategies to modulate innate and acquired immune responses.
"We examined whether transduction of murine DCs with adenoviral vectors (Adv) expressing interleukin (IL)-10 could alter their phenotype and T cell stimulatory function. Murine bone marrow-derived DCs were transduced with AdV encoding human IL-10 or green fluorescent protein (GFP). Whereas transduction of immature DCs with AdV/GFP resulted in dose-dependent...
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