Published in Medical Letter on the CDC and FDA, July 24th, 2005
In a recent report published in the journal Archives of Disease in Childhood, researchers in South Africa conducted a study "to define the pharmacokinetics of isoniazid (INH) in children with tuberculosis in relation to the N-acetyltransferase 2 (NAT2) genotype.
"The first order elimination rate constant (k) and area under the concentration curve (AUC) were calculated in 64 children <13 years of age (median 3.8) with respiratory tuberculosis from INH concentrations determined 2-5 hours after a 10 mg/kg INH dose."
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