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Dengue Virus Vaccine
DNA vaccine induces protective antibodies against dengue virus
July 24th, 2005
Tetravalent DNA immunization of mice with domain III of the envelope protein induced protective antibodies against dengue virus. "Dengue fever is a growing public health concern around the world and despite vaccine development efforts, there are currently no effective dengue vaccines. "In the present study we report the induction of protective antibodies against dengue virus by DNA immunization with domain III (DIII) region of the envelope protein (E) in a mouse model. The DIII region of all four dengue virus serotypes were cloned separately into pcDNA 3 plasmid. Protein expression was tested in COS-7 cells. Each plasmid, or a tetravalent...
Source: Medical Letter on the CDC & FDA (2005-07-24)
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