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Oncology

Interleukin 6 supports p53 tumor suppressor gene promoter methylation

Published in Medical Letter on the CDC and FDA, July 31st, 2005

Interleukin 6 supports p53 tumor suppressor gene promoter methylation.

"A strong association exists between states of chronic inflammation and cancer, and it is believed that mediators of inflammation may be responsible for this phenomenon. Interleukin 6 (IL-6) is an inflammatory cytokine known to play a role in the growth and survival of many types of tumors, yet the mechanisms employed by this pleomorphic cytokine to accomplish this feat are still poorly understood," scientists in the United States report.

"Another important factor in tumor development seems to be the hypermethylation of CpG islands located within the promoter regions of tumor...

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