HIV/AIDS Vaccine

Peptide capable of generating HIV-neutralizing activity identified

Published in Medical Letter on the CDC and FDA, July 31st, 2005

Scientists have identified a linear peptide recognized by monoclonal antibody 2D7 capable of generating CCR5-specific antibodies with human immunodeficiency virus-neutralizing activity.

According to recent research from the United States, "CCR5 is the major co-receptor for human immunodeficiency virus (HIV) infection. The murine monoclonal antibody (NMb) 2D7, which recognizes a conformation-dependent epitope in the second extracellular loop of CCR5, is one of the most potent inhibitors of R5 virus cell entry. However, attempts to humanize 2D7 for in vivo human use have been unsuccessful so far.

"A filamentous phage library expressing random peptides...

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Source: Medical Letter on the CDC and FDA (2005-07-31)

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