Measles Vaccine

Ability of measles protein to regulate genome replication examined

Published in Medical Letter on the CDC and FDA, July 31st, 2005

Scientists have identified naturally occurring amino acid variations that affect the ability of the measles virus C protein to regulate genome replication and transcription.

"The C protein of measles virus (MVC) is a basic protein of 186 amino acids (aa) that plays at least two roles in infected cells, interference with the innate immune response and modulation of viral polymerase activity. In this study, Northern blots were used to demonstrate that C proteins from three vaccine strains and three wild-type isolates of MV downregulated both mRNA transcription and genome replication in a plasmid-based mini-genome assay," researchers writing in the journal Virology...

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Source: Medical Letter on the CDC and FDA (2005-07-31)

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