HIV/AIDS Vaccine
Impact of HIV genetic diversity on vaccine development reviewed
Published in Medical Letter on the CDC and FDA, August 14th, 2005
"HIV-1 strains have diversified extensively through mutation and recombination since their initial transmission to human beings many decades ago in central Africa. The high error rate of HIV reverse transcriptase combined with the estimated in vivo HIV-1 replication rate of ten billion new virions each day leads to extraordinary genetic diversity of HIV. Twenty-seven circulating genetic forms of the HIV-1 group M are presently recognized, including 11 subtypes and sub-subtypes, and 16...
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