HIV/AIDS Pathogenesis

CD4 binding partially locks gp120 bridging sheet, leaves BETA2/3 strand flexible

Published in Medical Letter on the CDC and FDA, September 25th, 2005

CD4 binding partially locks the HIV gp120 bridging sheet, but leaves BETA2/3 strands flexible.

According to a study from the United States, "The structure of the free form HIV gp120, critical for therapeutic agent development, is unavailable due to its high flexibility. Previous thermodynamic data, structural analysis and simulation results have suggested a large conformational change in the core domain upon CD4 binding."

"The bridging sheet, which consists of four beta-strands with beta20/21 nestling against the inner/outer domains and beta2/3 facing outward, more exposed to the solvent, was proposed to be unfolded in the native state.

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Source: Medical Letter on the CDC and FDA (2005-09-25)

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