HIV/AIDS Epidemiology
HIV C77G polymorphism in exon 4 of CD45 gene is prevalent in Spanish population
Published in Medical Letter on the CDC and FDA, September 25th, 2005
"A mutation (C77G) in exon 4 of the CD45 gene is the most common cause of CD45 abnormal splicing in European populations, which has been associated with an increased susceptibility to human immunodeficiency virus infection. We aimed to analyze the C77G frequency in the Spanish population," investigators in Spain report.
"CD45RA and RO expression was determined in circulating T lymphocytes by flow cytometry in 517 healthy donors. CD45 exon 4 sequencing was carried out in individuals with an abnormal coexpression of CD45 isoforms," said the authors.
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