Susan Hasty, Publisher
Table of Contents . . . October 16th, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Medical Letter on the CDC and FDA | Other Publications
Environmental Health - Biologic monitoring of exposure to environmental chemicals discussed
Food-Borne Illness - Enrichment procedure for E. coli compared with standard methods
Glucose Monitoring - Accuracy of glucose monitors with different specimen matrices assessed
Pertussis Vaccine - Efficacy of pertussis vaccine in U.S. children examined
Adolescent Health - Fighting attributed to alcohol use among adolescent drinkers
Alzheimer Disease - Alzheimer disease study with Dimebon initiated
Anthrax Vaccine Development - Antibody patterns in anthrax vaccinees reported
Antimicrobial Resistance - Cross-resistance to antibiotics in M. tuberculosis examined
Aspergillosis - Recent findings in aspergillosis described
Diagnostics - Studies describe new findings in diagnostics research
Avian Influenza - Report: Drug-resistant avian influenza viruses more common in Southeast Asia
Biodefense - U.S. FDA grants fast track status to DVC biodefense vaccine development programs
Breast Cancer - Research add new data to breast cancer body of knowledge
Business & Finance - U.S. FDA issues warning letter to Ceph International
Business Update - Panel recommends conditional approval of Birmingham Hip Resurfacing technology
SARS - Studies advance knowledge in SARS research
Business Update - Response filed to support STS PMA application
Cancer Therapy - Enrollment completed in BLP25 liposome vaccine phase II study
Cancer Vaccines - Antigen-presenting cells induce higher-avidity human CTLs
Cancer Vaccines - CEA-based cancer vaccines reviewed
Cardiovascular Disease - Investigational drug trans NV-04 phase Ib clinical trial testing complete
Childhood Obesity - Prevalence of metabolic syndrome in obese Japanese children reported
Collaborations - Companies work to evaluate role of HIF-1alpha inhibition in treatment of cancer
Dengue Fever - Castanospermine is a potent inhibitor of dengue virus infection
Dermatology - Companies announce agreements to expand collaboration on dermatology products
Diabetes Epidemiology - Glucose intolerance in United Arab Emirates determined
Diabetes Risk Factors - Diabetes and ethnic minorities reviewed
Diabetes Therapy - Antidiabetic drug utilization in Hungary reviewed
Diabetes Therapy - U.S. FDA approves NovoLog for treatment of diabetes in children
Diagnostics - Assay identifies antigens that discriminate maximally between TB and non-TB sera
Diagnostics - Broad range 16S rDNA PCR and sequencing detects etiological agents of meningitis
Diagnostics - Coxsackievirus A detected by Enterovirus genus-specific markers
Diagnostics - ECL more sensitive andrapid than ELISA for C. botulinum type B detection
Diagnostics - MGE-PCR rapidly differentiates Central African T. brucei s.l. isolates
Diagnostics - Method for quantification of carvedilol in human plasma developed
Diagnostics - PCR sensitivity low for MTB detection from pleural effusion
Diagnostics - PCR-RADP assay discriminates L. ruminus from other Lactobacillus spp
Diagnostics - PCR-RFLP algorithm rapidly identifies mycobacteria at species level
Diagnostics - RT-loop-mediated isothermal amplification assay sensitive for RSV detection
Diagnostics - Reports describe recent advances in diagnostics research
Diarrhea Outbreaks - Simian SA11-human reassortant rotavirus G3P[8] strains cause of diarrhea
Disease Control - BSE crisis exposed public health undermined by governmental scientific control
Drug Delivery - DelSite files Drug Master File with U.S. FDA for GelSite mucosal applications
Drug Development - Beta-lactones have potent antimycobacterial activity
Drug Development - Diarylquinolones inhibit growth of Mycobacterium tuberculosis
Drug Development - First lot of Junovan manufactured to support marketing authorization filing
Drug Development - New repository for annotated electrocardiographic released
Drug Development - U.S. FDA accepts for review NDA for otic solution to treat external otitis
Drug Development - U.S. FDA approves IND for respiratory syncytial virus treatment
Drug Development - U.S. FDA grants Special Protocol Assessment for phase III trials for Miraxion
Drug Development - U.S. FDA grants final approval for Leflunomide for arthritis
Drug Development - U.S. FDA panel recommends approval of Pargluva for type 2 diabetes
Drug Resistance - LASIK-related mycobacterial infections in Brazil are fluoroquinolone-resistant
Drug Resistance - Multidrug-resistant bacterias emergence as a major hospital threat
Environmental Health - Autoreactive responses to environmental factors investigated
Environmental Health - Organochlorines and PCB congeners found in Korean human tissues
Epidemiology - Asymptomatic malaria underestimates prevalence in endemic areas
Epidemiology - HSV-2 specific serology improves diagnostic accuracy in high prevalent areas
Epidemiology - Tuberculosis incidence increasing in miners in Zambia
Epilepsy - NDA submitted to U.S. FDA for antiepileptic drug rufinamide
Food Safety - S. zooepidemicus from unpasteurized dairy causes glomerulonephritis epidemic
Food Safety - Shrimpers call for tests to ensure continued food safety in Katrina's wake
Food-Borne Illness - Histamine-producing bacteria found in mahi mahi and yellowfin tuna
Food-Borne Illness - Tolerances for residues of new animal drugs in food explained
Gastroenteritis - Rotavirus antigenemia reported in patients with acute gastroenteritis
Generic Drugs - Tentative approval granted by U.S. FDA for generic Pepcid AC tablets
Generic Drugs - U.S. FDA approval received for generic Glucophage XR Tablets
Generic Drugs - U.S. FDA approves ANDA for generic equivalent of rheumatoid arthritis tablets
HIV/AIDS Caregiving - Total care burden among chronically ill children higher than children with HIV
HIV/AIDS Epidemiology - HIV infection/risk characteristics determined for female sex workers in Hanoi
HIV/AIDS Epidemiology - Survey shows wealthy, educated women most vulnerable to HIV in Cameroon
HIV/AIDS HAART - Early therapy more cost-effective when impact of HAART on well-being is smaller
HIV/AIDS Infection - HIV-1 infects and replicates in oral mucosa
HIV/AIDS Therapy - U.S. FDA tentatively approves generic zidovudine oral solution for HIV/AIDS
HIV/AIDS Vaccine Development - HIV-1 env clones developed for vaccine-elicited neutralizing antibody assessment
HIV/AIDS Vaccines - Researchers' work adds to HIV/AIDS vaccines body of knowledge
HIV/AIDS-Associated Cryptococcosis - Azole use prevents invasive cryptococcal disease in HIV-infected patients
HIV/AIDSTesting - Standards organization gets agreement to improve HIV testing worldwide
Health Promotion - Colorectal cancer screening underutilized in HIV patients 50+ years old
Healthcare Insurance - Uninsured children who reportedly do not need health insurance investigated
Hepatitis C Virus - Biotech company announces research collaboration with medical college
Immunotherapy - DHEA treatment enhances the immune response to Trypanosoma cruzi
Infectious Diseases - Porcine circovirus type 2 has been in Switzerland for at least 19 years
Influenza Pandemic - Ethical issues related to preparations for influenza pandemic discussed
Influenza Vaccine - First phase of Maxim's flu shot program launched
Influenza Vaccine - Patient care team plays role in elderly decisions on influenza vaccine
Influenza Vaccine - Reasons for non-vaccination among healthcare workers explored
Influenza Vaccine - Vaccinating elderly against influenza is cost-effective in Mexico
Influenza Vaccine Development - Influenza vaccination in stem cell transplant recipients examined
Influenza Vaccine Development - U.S. government awards $100 million contract for avian influenza vaccine
Information Technology - U.S. FDA awards contract for integrated prescription, patient data system
Lead Poisoning - Environmental exposure to lead correlates with biochemical indices
Legal Issues - Court dismisses TriWest information theft lawsuit
Leishmaniasis Vaccine Development - Taenia crassiceps glycans act as adjuvant against leishmaniasis
Leishmaniasis Vaccine Development - Antigen expressing epitopes of Leishmania infantum developed
Leukemia - FDA advisory committee recommends accelerated approval of Arranon
Medical Devices - Study results on implantable device for treatment-resistant depression published
Medical Devices - Trocar-associated injuries and fatalities examined
Medical Devices - U.S. FDA grants marketing clearance for AngioSculpt Scoring Balloon Catheter
Medical Devices - U.S. FDA issues approvable letter for silicone gel filled breast implants
Medical Ethics - Risk perception and communicable disease vaccines examined
Meningococcal Vaccine Development - IgG against meningococcal capsular polysaccharide analyzed
Menstruation - Recruitment for Phase 3 efficacy study of menstrual migraine drug completed
Mental Health - Adverse childhood experiences increase risk of hallucinations
Metabolic Syndrome - Waist circumference identifies children at risk for metabolic syndrome
Mosquito-Borne Disease - Seasonal population density of anopheline mosquitoes in Korea reported
Mycobacterial Pathogenesis - Mutually dependent secretion of proteins required for mycobacterial virulence
Myelodysplastic Syndromes - U.S. FDA advisory committee recommends Revlimid for full approval
Norwalk Virus - Secretor status most predictive of Norwalk virus infection risk
Oncology - N+ and N- cutaneous malignant melanomas have different etiological pathways
Pain Management - European approval granted to market Precision Spinal Cord Stimulation system
Pancreatic Cancer - Panel recommends approval of Tarceva for pancreatic cancer
Patents - Second patent issued for amino acid platform to formulate challenging drugs
Patents - U.S. patent granted covering therapeutic products to treat hepatitis B virus
Pediatric Dermatology - Low birth weight increases risk of cutaneous opportunistic mold infections
Personnel - Michael Astrue named interim CEO of MRI pharmaceutical company
Pertussis Vaccine - Action to be taken when facing one or more cases of whooping cough
Pertussis Vaccine - Variations in B. pertussis isolates in Finland reported
Pneumococcal Vaccine - Cost-effectiveness of pneumococcal vaccination for infants reported
Polio Vaccine - Dynamic model of poliomyelitis outbreaks developed
Polio Vaccine - Vaccine-associated paralytic poliomyelitis in Brazil examined
Preventive Medicine - West Nile case counts rising, Illinois reports surge, California still tops list
Prostate Cancer - Clinical development of Teverelix LA on track after pre-IND application meeting
Prostate Cancer - Drugmaker to submit BLA to FDA for Provenge for advanced prostate cancer
Prostate Cancer - U.S. FDA responds to SPA for Acapodene for prevention of prostate cancer
Proteomics - HSP70 expression indicates early lung injury caused by exposure to arsenic
Respiratory Virus Outbreaks - RSV infection severity not changed by interference of influenza virus epidemics
Rheumatoid Arthritis - U.S. FDA lifts clinical hold on IND for PRTX-100
Rotavirus Epidemiology - Incidence of diarrhea from rotavirus infections in China reported
Rotavirus Epidemiology - Molecular epidemiology of rotavirus in South Korea presented
Rotavirus Vaccine - Burden of rotavirus disease in Malaysia estimated
Rotavirus Vaccine - Incidence of intussusception resulting from RotaShield estimated
Rotavirus Vaccine - Sentinel hospital data for rotavirus diarrhea in Taiwan reported
Rotavirus Vaccine Development - Epidemiological profile of rotaviral infection in India reported
Rotavirus Vaccine Development - Human rotavirus-bovine rotavirus reassortant vaccine developed
Rotavirus Vaccine Development - Live, attenuated rotavirus vaccine evaluated in Singaporean infants
Rotavirus Vaccine Development - Pentavalent rotavirus vaccine against gastroenteritis developed
SARS - Reports advance knowledge in SARS research
SARS - Two neutralizing antibody assays developed against SARS coronavirus
SARS Vaccine - Antibodies to SARS-associated coronavirus proteins identified
Schistosomiasis Vaccines - Research add new data to schistosomiasis vaccines body of knowledge
Sexual & Reproductive Health - U.S. FDA approves ParaGard IUD for women who have not yet had children
Smallpox Diagnosis - Physicians lack some knowledge about initial presentation of smallpox
Smallpox Vaccine - Humoral antiviral immunity persists within the Japanese population
Stroke - U.S. FDA grants approval for device to treat patients at risk of stroke
Surgical Technology - Technology company receives approval for Hover-T Bridge for spinal surgery
Surgical Technology - U.S. FDA issues approvable letter for ceramic-on-ceramic hip system
Tetanus Vaccine - Tetanus immune status in plasma donors of Bavarian Red Cross reported
Tissue Engineering - PCL scaffold does not support full osteoblastic phenotype expression
Treatment-Resistant Depression - TRD third-party payer coverage status and plan explained
Tuberculosis - Inverse association between MTB infection and atopic rhinitis in children exists
Tuberculosis Diagnosis - Whole-blood test developed for diagnosis of active tuberculosis
Tuberculosis Vaccine Development - DNA vaccine effective in murine model of tuberculosis infection
Tuberculosis Vaccines - Findings advance knowledge in tuberculosis vaccines research
Type 1 Diabetes - U.S. FDA committee recommends approval of Exubera
Vaccine Efficacy - Measurement of serum bactericidal activity standardized
West Nile Virus - Severe neurological disease risk higher in transplant patients who acquire WNV
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