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Anthrax Vaccine Development

Antibody patterns in anthrax vaccinees reported

Published in Medical Letter on the CDC and FDA, October 16th, 2005

Researchers describe protective antigen and toxin neutralization antibody patterns in anthrax vaccinees undergoing serial plasmapheresis in a recent issue of Clinical and Diagnostic Laboratory Immunology.

"Recipients of licensed anthrax vaccine (AVA; Biothrax) could serve as a source of hyperimmune plasma and immunoglobulin for therapy and prophylaxis. We measured serum antibodies during serial weekly to biweekly plasmapheresis in 38 individuals previously vaccinated with 4 to 27 doses of AVA. Immunoglobulin G (IgG) to protective antigen (PA) and toxin neutralization assay (TNA) antibody levels were highly correlated (r=0.86930 and p<0.0001 for anti-PA...

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