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Drug Development
Lipophilic antifolate trimetrexate inhibits Trypanosoma cruzi
October 23rd, 2005
Lipophilic antifolate trimetrexate inhibits Trypanosoma cruzi. "Trypanosoma cruzi, a protozoan parasite, is the causative agent for Chagas' disease, which poses serious public health problem in Latin America. The two drugs available for the treatment of this disease are effective only against recent infections and are toxic," investigators in the United States report. "Dihydrofolate reductase (DHFR) has a proven track record as a drug target. The lipophilic antifolate trimetrexate (TMQ), which is an FDA-approved drug for the treatment of Pneumocystis carinii infection in AIDS patients, is a potent inhibitor of T. cruzi...
Source: Medical Letter on the CDC & FDA (2005-10-23)
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