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Fosinoprilat
LC method to measure fosinoprilat in plasma developed
October 23rd, 2005
Scientists have developed a liquid chromatographic (LC) method for fosinoprilat determination in human plasma using a micro-emulsion as the eluent. According to recent research from Serbia and Montenegro, "Fosinopril sodium presents a prodrug for the active angiotensin-converting enzyme (ACE) inhibitor, fosinoprilat. The dual elimination of fosinoprilat by the liver and the kidney distinguishes fosinopril from other angiotensin-converting enzyme inhibitors. Such ways of elimination are important for antihypertensive therapy of patients on hemodialysis. The paper presents development and evaluation of a new and sensitive liquid chromatographic method for the analysis of...
Source: Medical Letter on the CDC & FDA (2005-10-23)
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