Malaria Vaccine Development
P36p-deficient malarial sporozoites protect infected liver cells
Published in Medical Letter on the CDC and FDA, October 30th, 2005
"Immunization with Plasmodium sporozoites that have been attenuated by gamma-irradiation or specific genetic modification can induce protective immunity against subsequent malaria infection. The mechanism of protection is only known for radiation-attenuated sporozoites, involving cell-mediated and humoral immune responses invoked by infected hepatocytes cells that contain long-lived, partially developed parasites. Here we analyzed sporozoites of Plasmodium berghei that are deficient in P36p (p36p-), a member of the P48/45 family of...
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