Apoptosis
Macrophage apoptosis activation incomplete during L. pneumophila infection
Published in Medical Letter on the CDC and FDA, October 30th, 2005
According to recent research published in the journal Infection and Immunity, "The ability of the intracellular bacterium Legionella pneumophila to cause disease is totally dependent on its ability to modulate the biogenesis of its phagosome and to replicate within alveolar cells. Upon invasion, L. pneumophila activates caspase-3 in macrophages, monocytes, and alveolar epithelial cells in a Dot/Icm-dependent manner that is independent of the extrinsic or intrinsic pathway of apoptosis, suggesting a novel mechanism of caspase-3 activation...
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