Susan Hasty, Publisher
Table of Contents . . . November 6th, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Medical Letter on the CDC and FDA | Other Publications
Hemophilia Therapy - Republic of Georgia develops successful national hemophilia program
Measles Vaccine - Measles control program reduces measles deaths by 20% in Africa
Natural Products - Russian ethnomedicinal plants more cytotoxic than established therapies
Neural Tube Defects - Prevalence of spina bifida and anencephaly declining in U.S. minorities
Sexually Transmitted Diseases - Phone call more cost-effective than counseling for prompting follow-up clinic visits
Adverse Drug Reaction - Agencies issue alert on Menactra meningococcal vaccine and Guillain Barre syndrome
Adverse Drug Reaction - Agency issues public health advisory on Strattera (atomoxetine) for attention deficit disorder
Adverse Drug Reaction - Anaphylaxis risk for rocuronium comparable to vecuronium
Antimicrobials - Studies add new findings to antimicrobials body of knowledge
Antipsychotics - Adherence to clozapine therapy improved by weekly clinician visits
Asthma - FDA approves Zyflo for prevention and treatment of asthma
HIV/AIDS Vaccines - Researchers' findings advance HIV/AIDS vaccines research
Asthma - New study on childhood asthma shows home-based interventions are cost effective
Bacterial Vaginosis - Vaginal IL-8 levels not associated with bacterial vaginosis during pregnancy
Biomedical Engineering - Nitric oxide-releasing coatings reduce implant-associated infections
Bioterrorism - U.S. NIH awards $4.6 million challenge grant for R&D of intranasal anthrax vaccine
Blood Glucose - Approved IFCC recommendation for reporting blood glucose results released
Blood Safety - New system increases platelet availability and patient safety
Blood Safety - Photochemical treatment inactivates Leishmania in platelet concentrates
Breast Cancer - U.S. FDA approves Aromasin for adjuvant treatment of early breast cancer in postmenopausal women
Breast Cancer - U.S. Food and Drug Administration approves InSite HER-2/neu (CB11) monoclonal antibody
Cancer Risk Factors - Red meat and meat cooked at high temperatures associated with higher cancer risk
Cancer Risk Factors - Susceptibility to carcinogens increased with early-life exposure
Cancer Therapy - Guidance documents for marketing approvals of anticancer drugs in Europe need rewriting
Cancer Vaccines - Studies describe new findings in cancer vaccines research
Cardiovascular Disease - CV disease prevention guidelines should focus on older patients
Childhood Obesity - Australian general practitioners tackle childhood obesity in LEAP program
Childhood Obesity - Time watching TV or playing outdoors not linked to BMI in preschool children
Clinical Trials - Completing phase 3 study plan of testosterone for HSDD is result of U.S. FDA meeting
Clinical Trials - Stem cell products company announces clinical hold on enrollment in CB001 study
Clinical Trials - U.S. FDA grants clearance to conduct clinical studies for myelodysplastic syndrome
Clinical Trials - U.S. phase II trial for cholesterol-lowering drug, FM-VP4, cleared
Contraception - Increased access to emergency contraception does not increase sexual risk behavior
DNA Research - U.S. NIH medical sciences institute awards grant for biomolecule labeling method
Defibrillators - U.S. Food & Drug Administration approves new implantable defibrillator system
Diabetes Therapy - Lack of infrastructure limits access to care for patients with insulin-requiring diabetes
Diagnostics - Bacterial 16S rDNA universal primers diagnose partially treated meningitis
Diagnostics - ELISAs are accurate for screening community levels of Cryptosporidium infection
Diagnostics - FDA clears use of Stratus CS Acute Care D-dimer assay as aid in VTE diagnosis
Diagnostics - PCR-SSCP rapidly identifies Neisseria meningitidis
Diet & Nutrition - New U.S. Dept. of Agriculture computer-based MyPyramid food guidance system for children applauded
Diet & Nutrition - Problems with Cochrane reviews of diet and chronic disease examined
Drug Development - Biotech company meets with U.S. FDA for IND application on colon cancer drug
Drug Development - Clinical endpoints achieved in phase II trial of anti-nausea drug
Drug Development - European and U.S. orphan drug designation granted for cardiogenic shock medication
Drug Development - FDA grants fast track designation for arimoclomol in ALS
Drug Development - Pharmaceutical company to request end of phase II meeting with U.S. FDA for CF drug
Drug Development - Phase I trial to be initiated for AVN944 to treat hematological malignancies
Drug Resistance - Single MRSA clone spreading transregionally between drug users in Switzerland
Drug Safety - Healthcare providers notified of adverse events from Menactra meningococcal vaccine
Epidemiology - Widespread B. cenocepacia clone identified in CF patients in Czech Republic
Fitness & Wellness - Athletes and nonathletes with similar body fat have same lipidemic profiles
Fluorosis - Serum fluoride levels correlate with prevalence of skeletal fluorosis
Food-Borne Illness - Benzo(a)pyrene induces anemia and splenomegaly in NZB/WF1 mice
Gastroenterology - Gastrointestinal disease may be a risk factor for GI infection with Listeria
Genetics & Genomics - SNCG gene expression by demethylation a critical factor to malignant progress
Genital Herpes Vaccine - Majority of parents would allow children to be vaccinated against genital herpes
Genital Warts - New drug application filed with U.S. Food and Drug Administration for Polyphenon E Ointment
Geriatrics - Pneumococcal immunizations more likely in nursing homes with vaccine programs
Glioblastoma Therapy - Radiation plus IL-13 receptor-targeted cytotoxin kill glioblastoma cells
Gynecology - Pathology of NovaSure impedance-controlled endometrial ablation system described
HIV/AIDS Diagnostics - Plasma RT assay is an affordable alternative for HIV viral load determination
HIV/AIDS Drug Development - Protease inhibitors plus mefloquine have marked synergy against HIV-1
HIV/AIDS HAART - Cotrimoxazole prophylaxis prevents complications prior to HAART initiation
HIV/AIDS HAART Prophylaxis - Adherence to HAART prophylaxis is low in victims of suspected sexual abuse
HIV/AIDS Pathogenesis - Saliva HIV levels more influenced by blood HIV RNA levels than oral inflammation
HIV/AIDS Pathogenesis - Vpr-mediated cell cycle arrest is important for HIV replication and pathogenesis
HIV/AIDS Prophylaxis - Single-dose nevirapine within 24 hours of birth protects against HIV-1 infection
HIV/AIDS Transmission Risk - Second trimester amniocentesis does not increase vertical HIV transmission risk
HIV/AIDS Vaccines - Research add new data to HIV/AIDS vaccines body of knowledge
HIV/AIDS-Associated Infection - TSP/HAM should be considered in HIV patients with myelopathy and normal CD4 counts
HIV/AIDS-Related Infection - HIV-1 infection is not a risk factor for amebiasis
Heart Failure - Higher levels of CRP are associated with more severe heart failure
High Triglycerides - Pharma company launches Omacor to treat very high levels of triglycerides
Human Papillomavirus - Recent findings illuminate research in human papillomavirus
Hurricane Relief - U.S. Department of Health & Human Services awards grants to support minority health
Imaging - Cancer-focused imaging company withdraws PMA supplement submission to U.S. FDA
Imaging - U.S. Food & Drug Administration clears new fluoroscopic imaging system, called the OEC Altitude
Immune Thrombocytopenic Purpura Therapy - Disseminated intravascular coagulation is rare complication of anti-D IGIV therapy
Influenza - AIV TX/04 pathogenicity increased by AA insertion at hemagglutinin cleavage site
Influenza - H5N1 influenza virus is nonpathogenic in ducks
Influenza - Oral lactoferrin and lactoperoxidase attenuates pneumonia in influenza virus infection
Influenza Vaccine - U.S. NIAID and MedImmune join forces to develop potential pandemic influenza vaccines
Influenza Vaccines - New research in the area of influenza vaccines detailed
Keratoplasty - U.S. Federal Aviation Administration approves use of conductive keratoplasty for pilots
Laboratory Biosafety - Biosafety level 3 facilities safeguard from SARS-CoV-infected autopsy specimens
Lead Poisoning - Low blood lead levels affect cardiovascular functioning in children
Legal Issues - Appeals court upholds patent infringement finding on BenchMark, Discovery claims
Malaria - Puddles created by the 2004 tsunami facilitate increased breeding of malaria vector
Malaria Therapy - Quinine monotherapy does not effectively treat malaria in pregnant women
Malaria Vaccines - Recent findings in malaria vaccines described
Medical Devices - Life science company enters two agreements with TZ Medical for the acquisition cardiac devices
Medical Devices - Light-based skin therapy company receives U.S. government clearance for hair removal
Medical Devices - Medical devices company receives U.S. FDA clearance for extraction catheter
Medical Devices - Premarket approval application submitted to U.S. Food and Drug Administration for rhBMP-2
Medical Devices - U.S. FDA grants approval for tiny blood glucose monitor, Sidekick
Medical Errors - Language increase risk of serious medical events in hospitalized children
Medical Errors - Professionals alerted to reported medication errors between Topamax, Toprol-XL
Mental Health - Placebos should be used for testing of new psychiatric disorder agents
Microbicide - Vaginal detergent-type microbicide causes inflammatory cell infiltration at epithelial surface
Microsporidia Infection - Early symptoms of microsporidia infection may resolve even though microsporidia may persist
Myelodysplastic Syndrome - Revlimid action date for U.S. Food and Drug Administration priority review of NDA extended
Nanotechnology - Safety evaluation of nanomaterial exposure suggested
Nosocomial Infection - Nosocomial bacteremia in neonates is related to poor standards of care
Obesity Diagnosis - Waist circumference criteria for abdominal obesity not applicable to all populations
Occupational Health - Steelworker cohort in Korea exhibits excess mortality for some processes
Parasitology - Flea larvae have higher survival when parasitizing underfed hosts
Personnel - WHO health expert David Nabarro named work on avian, human influenza response
Pertussis Vaccines - Data advance knowledge in pertussis vaccines research
Pneumococcal Vaccines - Reports describe recent advances in pneumococcal vaccines research
Polio Vaccines - Studies describe new findings in polio vaccines research
Product Licensing - Oncology drug acquired from SD Pharmaceuticals through exclusive license agreement
Proteomics - More proteins accumulate in stored supernatants of nonleukoreduced than in leukofiltered RBC products
Psoriasis - European Commission grants approval of Remicade for plaque psoriasis
Psoriatic Arthritis - Humira receives U.S. Food and Drug Administration approval for treatment of psoriatic arthritis
Radiology - Regulatory requirements for human subjects in radiology research outlined
Regulatory Approvals - Marketing clearance for the ULTRIO assay on the TIGRIS system "unlikely" this year
Research Funding - Cell culture developer receives $3.96 million U.S. DoD contract to continue R&D
Research Funding - Gene researcher awarded $4.9 million U.S. NIH contract for knockout mouse materials
SARS - Acute SARS-CoV infection contributes to initial DC and T-cell subset reduction
SARS - Imported cases after nosocomial infection were major cause of SARS infections
SARS Outbreaks - Data advance knowledge in SARS ouTBreaks research
Salmonellosis Therapy - Beta-lactam resistance investigated in Enterobacteriaceae
Sepsis Prevention - Six sigma strategies reduce incidence of catheter-related bloodstream infections
Sexual Dysfunction - Testosterone therapy in women reviewed
Shigellosis Outbreak - Researchers report shigellosis outbreak in swimmers in freshwater lake
Sleeping Sickness - Sleeping sickness epidemic spreading in Uganda
Smallpox - Vaccine, previously left unused in WHO eradication program, provides efficient protection
Staffing - Concentra secures military contract to provide on-site occupational medicine services
Stem Cell Transplantation - New research in the area of stem cell transplantation detailed
Tuberculosis Risk Factors - Population-based TB risk factors for Tibetan refugees in India reported
Type 2 Diabetes - Personal characteristics affect quality of life in diabetic patients in Iran
Ultrasonography - Greater standardization of ultrasound backscatter measurement methods needed
Variant Creutzfeldt-Jakob Disease Prion - Transmission risk of v-CJD prion during abdominal surgery is currently unquantifiable
Vibrio Fluvialis - Vibrio fluvialis isolated from pediatric patients with diarrhea
Violence - Almost 1.7 million children at risk from loaded firearms in U.S.
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