Biomedical Engineering
Nitric oxide-releasing coatings reduce implant-associated infections
Published in Medical Letter on the CDC and FDA, November 6th, 2005
"The in vivo antibacterial activity of nitric oxide (NO)-releasing xerogel coatings was evaluated against an aggressive subcutaneous Staphylococcus aureus infection in a rat model.
"The NO-releasing implants were created by coating a medical-grade silicone elastomer with a sol-gel-derived (xerogel) film capable of storing NO," scientists in the United States report.
"Four of the bare or xerogel-coated silicone materials were subcutaneously implanted into male rats. Ten rats were administered 10 mcL of a 108 cfu mL-1...
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