Susan Hasty, Publisher
Table of Contents . . . November 27th, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Medical Letter on the CDC and FDA | Other Publications
Anti-infectives - Antimicrobial use common in U.S. neonatal and pediatric intensive care patients
Avian Influenza - Evolution of H5N1 avian influenza viruses in Asia outlined
Genetics & Genomics - New measles genotype identified in Uganda
Influenza A Virus - Concerns raised about increasing adamantane resistance in influenza A viruses
Adenovirus - Vitronectin enhances tropism of adenovirus type 19 for the cornea
Aspergillosis - Data advance knowledge in aspergillosis research
Atopic Dermatitis - MimyX Cream cleared for sales and marketing in the United States
Attention Deficit Hyperactivity Disorder - SPARLON, for treatment of ADHD in children and adolescents, receives approvable letter
Avian Influenza - Animal health group confirms avian influenza in domestic birds in Turkey
Avian Influenza - U.S. agency announces rapid response team to combat avian flu
Awards - LSU researcher receives $485,000 U.S.NIH grant to study Friedreich's ataxia
Besnoitiosis Outbreaks - Besnoitiosis outbreak occurred in miniature donkeys in the U.S.
Bioterrorism - Electronic tongue developed to perform initial palatability screening
Botulism - Mass spectrometric method developed to differentiate botulinum neurotoxins
Business & Finance - Respiratory home care services company reports impact of Medicare on revenues
Campylobacter - C. jejuni mobilizes Ca2+ from host intracellular stores
Cancer Therapy - Anticancer drug gets fast track for elderly with acute myelogenous leukemia
Collaborations - Alliance signed with the U.S. CDC for research and development of a Pneumococcus vaccine
Complementary & Alternative Medicine - Seventy milligrams of zinc weekly reduces mortality in young children
Diabetes Epidemiology - Reports advance knowledge in diabetes epidemiology research
Diagnostics - Automated screening assay detects anti-SARS coronavirus agents
Diagnostics - Best performing sampling strategy for two and three diagnostic methods described
Diagnostics - High-throughput assay detects down to 1.25 ng/ml piperaquine in plasma
Diagnostics - Interlaboratory reliability achieved in PCR-based detection of Mycobacterium tuberculosis
Diagnostics - MAP infection in ruminants may be implicated in the pathogenesis of Morbus Crohn disease
Diagnostics - Prediction rule helps to clinically diagnoses SARS
Diagnostics - Scrotal MRI and urinary PCR allow prompt diagnosis of tuberculous epididymitis
Disease Control - Culex restuans has an important role in West Nile virus transmission
Disease Control - Barmah Forest virus is an important public health risk in Queensland, Australia
Disease Control - Nonbrothel based female sex workers at higher risk of HIV infection than brothel workers
Disease Vectors - Ectoparasites found on house mice from pet stores in South Carolina
Drug Delivery - Intramuscular administration of antimalarial drug arteether appears to be most potent
Drug Delivery - Rifampicin-loaded PLGA microspheres deliver drug into MTB-residing alveolar macrophages
Drug Development - Aryloxyphenyl cyclopropyl methanones active against multidrug resistant Mycobacterium tuberculosis
Drug Development - First human trial for AT-1001 completed; U.S. FDA grants fast-track designation
Drug Development - Isoniazid derivatives inhibit Mycobacterium tuberculosis
Drug Development - Letter issued from U.S. FDA on Dapoxetine application
Drug Development - Pharma companies report regulatory status of decitabine injection for MDS
Drug Development - Phase I study results of BLX-883 in hepatitis patients support continued development
Drug Development - Phase III clinical trial initiated in U.S. of treatment for head lice
Drug Development - Regulatory approval sought in Europe for Junovan as osteosarcoma therapy
Drug Development - Threshold of toxicological concern applied to drug manufacturing
Drug Resistance - Cross-resistance between rifampicin and rifabutin detected in 73.1% of active pulmonary TB
Drug Resistance - Drug-resistant pulmonary TB in western Turkey is higher in patients with treatment failure
Drug Resistance - Multidrug resistant tuberculosis inversely associated with successful outcome
Emergency Medicine - Most return visits to EDs in 2002 were for follow-up services
Environmental Health - Researchers provide details of new studies and findings in the area of environmental health
Environmental Risk - Water may be a significant reservoir of M. avium subsp. paratuberculosis infection
Epidemiology - P. falciparum parasites infecting a primitive tribe has a low level of polymorphisms
Epidemiology - Spatial dynamics of Lyme disease in New York State from 1990-2000 investigated
Epilepsy - Application filed for treatment of myclonic seizures in juveniles
Finance - Antibody-based drug developer reports net loss; initiates clinical trial
Finance - Biopharma company reports third quarter net income of $26.2 million
Finance - Leukemia drug developer reports loss of $0.29 per share, reports clinical pipeline update
Finance - OxyAlert maker files 10-KSB to become a reporting company
Fluoxetine - Flutin bioequivalent to Prozac
Food Safety - Inadequate meat inspection programs associated with trichinellosis outbreaks in Serbia
Gastroenterology - Infectious diarrhea is a major cause of childhood mortality in developing countries
Generic Drugs - Express Scripts study shows substantial savings opportunities with generics, says industry group
Generic Drugs - U.S. FDA grants tentative approval for ribavirin
Genetics & Genomics - Measles virus genotypes from outbreaks in the Eastern Mediterranean region have been identified
HIV/AIDS Depression - HIV-infected rural men have higher rates of depression risk than infected urban men
HIV/AIDS Disease Control - HIV/AIDS knowledge is lacking in paramedical students in Saudi Arabia
HIV/AIDS Epidemiology - HLA class II alleles associated with HIV-1 pathogenesis in Botswana
HIV/AIDS Pathogenesis - Recent findings illuminate research in HIV/AIDS pathogenesis
HIV/AIDS Therapy - Researchers describe findings in HIV/AIDS therapy studies
HIV/AIDS Vaccine - Targeting the Env lipid domain inactivates HIV and SIV
HIV/AIDS Vaccines Development - Studies add new findings to HIV/AIDS vaccines development body of knowledge
HIV/AIDS-Related Stroke - Protein S deficiency occurs more frequently in HIV+ compared with HIV- stroke patients
Healthcare Costs - Isoniazid is cost-effective for reducing TB burden in recently converted persons
Heart Disease Risk Factors - Prolonged QTc interval indicates cardiovascular risk
Hepatitis B Virus - Ongoing transmission of hepatitis B among prison inmates reported
Hepatitis C Therapy - Tentative approval granted for hepatitis C combination therapy
Human Papillomavirus - Chlamydia trachomatis linked to persistence of high-risk HPV types
Immunization - Immunization awareness organization supporting Tdap booster
Infectious Diseases - Economic crisis has triggered re-emergence of infectious diseases in Madagascar
Information Technology - Radio frequency identification infant protection system introduced in the U.K.
Marketing - Companies form marketing relationship for colorectal cancer testing
Medicaid - Secretary Mike Leavitt names Governors Bush and Manchin as new Medicaid Commission voting members
Medical Devices - Biopharma inks letter of intent with U.S. CDC to enter into CRADA
Medical Devices - U.S. FDA grants 510(k) clearance for additional data in Tumor Cell Kit
Medical Policy - Stem cell research policy proposed
Medicare - Centers for Medicare and Medicare Services announces coding decision
Medicare - Survey finds Part D awareness high, but familiarity and knowledge remain low
Metabolic Syndrome - Researchers' data advance metabolic syndrome research
Myelodysplastic Syndromes - Pharma company seeking authorization to market Revlimid in European Union
Nosocomial Infections - K. pneumoniae nosocomial outbreak strains in 1997 and 2005 not clonally related
Nosocomial Infections - Patients infected with nosocomial bacteria generate nonresistant and resistant strains
Ophthalmology - Pharma company executes agreement to promote treatment for dry eye disease
Pain Management - Arthroscopic treatment improves stability and reduces pain
Parasitology - Raccoons are a naturally occurring intermediate host of Neospora caninum
Personnel - Agency names new director of drug safety; goals for center for drugs reorganization announced
Respiratory Distress Syndrome - U.S. FDA accepts complete response to approvable letter for Surfaxin
Respiratory Medicine - Tuberculosis is an uncommon but definite cause of acute respiratory distress syndrome in ICUs
Rhinitis - PreHistin significantly reduces allergy symptoms in 714-patient phase III clinical trial
SARS - Data advance knowledge in SARS research
SARS - Death rate caused by SARS CoV genotype C is lower than that of genotype T
SARS - Rhabdomyolysis is associated with acute renal failure in SARS patients
Salmonella Outbreak - Nationwide Salmonella outbreak in Germany associated with raw minced pork
Severe Primary IGF-1 Deficiency - U.S. FDA to review response to approvable letter for iPlex
Sociology Research - Liverpool cholera riots of 1832 demonstrate the complex social response to epidemic disease
Stem Cell Research - Clearance granted for phase I trial of neural stem cells to treat Batten disease
Stem Cell Transplantation - Bone marrow remains a significant source of stem cells for autologous HSCT
Streptococcus Diagnosis - Pyrosequencing differentiates Streptococcus pneumoniae serotypes
Surgical Technology - Medical device company files investigational device exemption for NeoDisc
Surgical Technology - U.S. FDA grants clearance to market skin renewal system for fine lines, wrinkles
Teratogen - 4-Aminobiphenyl induces liver mutations only in neonatal mice
Thymus - Cytokine up-regulation important for thymus reconstitution
Tuberculosis Epidemiology - Prevalence of tuberculosis elevated among correctional inmates
Tuberculosis Vaccine - Antimycobacterial antibodies enhance innate and cell-mediated immunity
Type 1 Diabetes - U.S. FDA approves Levemir for treatment of diabetes in children
Vaccine Delivery - Cytokines inducted by heat-killed Brucella depend on triggering TLR9
Vaccines Vector - Researchers' data advance vaccines vector research
Yellow Fever Vaccines - Reports advance knowledge in yellow fever vaccines research
Zoonosis - Interspecies transmission of Enterozytozoon bieneusi is possible
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