Drug Delivery
Rifampicin-loaded PLGA microspheres deliver drug into MTB-residing alveolar macrophages
Published in Medical Letter on the CDC and FDA, November 27th, 2005
According to recent research from Japan, "Pulmonary surfactants little affected the release ratio of rifampicin from rifampicin-loaded poly(lactide-co-glycolide) PLGA microspheres.
"The release ratio of rifampicin was depending on pH of pulmonary surfactant solution, showing that rifampicin-loaded PLGA microspheres have an ideal property to deliver rifampicin into alveolar macrophages inside of which Mycobacterium tuberculosis bacilli reside and to kill them."
"That is," the authors continued, "little...
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