Typhus Vaccine
Scrub typhus vaccine candidate induces immune responses in monkeys
Published in Medical Letter on the CDC and FDA, December 18th, 2005
According to recent research from the United States, "A truncated recombinant 56-kDa outer membrane protein of the Karp strain of Orientia tsutsugamushi (Kp r56) was evaluated in cynomolgus monkeys (Macaca fascicularis) for immunogenicity and safety as a vaccine candidate for the prevention of scrub typhus. This recombinant antigen induced strong humoral and cellular immune responses in two monkeys and was found to be well tolerated. Antigen-specific immunoglobulin M (IgM) and IgG were produced to almost maximal levels within one week of a single...
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