Tuberculosis Vaccine
Sindbis virus-based DNA vaccine protects against M. tuberculosis
Published in Medical Letter on the CDC and FDA, January 1st, 2006
According to scientists in the United States, "To improve DNA vaccination against Mycobacterium tuberculosis, we evaluated the effectiveness of a Sindbis virus-based DNA construct expressing the tuberculosis antigen 85B (Sin85B)."
"The protective efficacy of Sin85B was initially assessed by aerogenically challenging immunized C57BL/6 mice with virulent Mycobacterium tuberculosis. At one and seven months post-infection, the lung bacterial burdens were considerably reduced and the lung pathology...
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