Medical Letter on the CDC and FDA

Amebiasis Diagnosis - Report compares real-time PCR protocols for differential diagnosis of amebiasis

Hemophilia Epidemiology - Report reviews demographics of hemophilia in developing countries

Streptococcus Epidemiology - Clonal association found between Streptococcus pneumoniae serotypes 23A and 23F

Vaccine Efficacy - Hepatitis A immunization program aimed at child-care centers proves successful

Acute Lymphoblastic Leukemia - European study confirms efficacy of clofarabine in pediatric patients with ALL

Acute Peripheral Arterial Occlusion - U.S. FDA specifies protocol for phase III trial of novel arterial perfusion with alfimeprase-3

Adverse Drug Reaction - Agency advises of risk of birth defects with Paxil

Age-Related Macular Degeneration - EMEA to issue updated positive opinion and recommendation of Macugen for AMD

Alcoholism Therapy - Review examines medications for treating alcohol dependence

Anti-Infectives - Research in Anti Infectives provides new insights

Attention Deficit Hyperactivity Disorder - Pharma company commences manufacturing of patch for ADHD

Autism - New drug-development company with a focus on dysautonomia reports positive meeting with U.S. FDA

Avian Influenza - Highly pathogenic avian influenza H5N1 epidemic is ongoing in Thailand

Bioterrorism - Regulations devised for international assistance related to chemical weapons

Breast Cancer - Studies evaluate impact of switching on survival in adjuvant treatment of early breast cancer

Business & Finance - orBec maker receives extension to comply with AMEX listing standards

Business Update - Ophthalmic pharmaceutical maker announces U.S. FDA inspection results

Business Update - Vasovist maker to reduce workforce

COX-2 Inhibitors - COX-2 inhibitors may disrupt inflammatory PG balance, resulting in reported adverse effects

Chemotherapy - Potential signal for arrhythmias and cardiac arrest are found with dolasetron

Childhood Obesity - Report reviews pharmacotherapy of childhood and adolescent obesity

Childhood Obesity - Research is needed to determine efficacy of strategies to treat childhood obesity

Collaborations - Roche files IND with U.S. FDA for antibody developed under collaboration

Colorectal Cancer - Two new clinical sites added for colorectal drug trial in Israel

Consumer Protection - Agency acts to protect public from fraudulent avian flu therapies

Dengue Virus - Reports advance knowledge in Dengue Virus research

Diagnostics - Data advance knowledge in diagnostics research

Disease Control - High morbidity continues to be associated with diarrheal diseases

Drug Development - Avelox approved in U.S. to treat complicated intra-abdominal infections

Drug Development - European phase III trial for Miraxion in Huntington disease commences

Drug Development - Phase I study to evaluate ALN-RSV01 for the treatment of respiratory syncytial virus

Drug Development - U.S. FDA approval granted for Carbamazepine tablets USP as anticonvulsant

Drug Development - U.S. FDA approval granted for generic version of OxyContin in three strengths

Drug Development - U.S. FDA grants approval for Azithromycin for injection

Drug Development - U.S. FDA issues approvable letter for Diquafosol

Drug Resistance - Emerging resistance in foodborne pathogens increase burdens of illness and outbreaks

Drug Resistance - Reports advance knowledge in Drug Resistance research

Environmental Health - Method to detect phthalate metabolites in human saliva is developed

Environmental Health - Method to recover microbes in drinking water by ultrafiltration is developed

Epidemiology - Dental health disparities among Israeli 12-year-olds reported

Epidemiology - Population trend estimates based on respondent data are likely biased