Allergy & Immunology
Decreased CD4 expression by polarized T helper 2 cells influences TCR signaling
Published in Medical Letter on the CDC and FDA, January 22nd, 2006
"Polarized Th1 and Th2 cells expressing the same TCR produce distinct biochemical responses to ligand engagement. Compared to Th1 cells, Th2 cells show altered substrate tyrosine phosphorylation and a diminished or transient Ca2+ response."
Y. Itoh and colleagues, U.S. National Institute of Allergy and Infectious Diseases, wrote, "Here we demonstrate that agonist stimulation of Th1 cells leads to the predominant appearance of fully phosphorylated (p23) TCR zeta, substantial phosphorylation of...
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