Tularemia Vaccine
Attenuated Francisella tularensis mutant is an effective live vaccine
Published in Medical Letter on the CDC and FDA, January 29th, 2006
"Francisella tularensis subspecies tularensis (type A) strain SCHU S4 is a prototypic strain of the pathogen that is highly virulent for humans and other mammals. Its intradermal (i.d.) 50% lethal dose (LD50 ) for mice is <10 CFU. We discovered a spontaneous mutant, designated FSC043, of SCHU S4 with an i.d. LD50 of >108 CFU. FSC043 effectively vaccinated mice against challenge with a highly virulent type A strain, and the protective efficacy was...
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