Carcinogenesis
Domain functions of p63 isotypes regulate different aspects of epidermal homeostasis
Published in Medical Letter on the CDC and FDA, March 5th, 2006
According to a study from the United States and Japan, "P63 is critical for squamous development and exists as multiple isotypes of two subclasses, TA and Delta N. Delta Np63 isotypes can antagonize transcription by TAp63 and p53, and are highly expressed in squamous cell cancers. Using mouse keratinocytes as a biological model of squamous epithelium, we show that multiple p63 isotypes, Delta N- and TA-containing, are expressed and differentially modulated during in vitro murine keratinocyte differentiation."
"Delta Np63 alpha declines with...
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