Oncology
Cancer metastasis in xenograft models is altered by interleukin-1 blockade
Published in Medical Letter on the CDC and FDA, April 19th, 2006
"Interleukin 1 (IL-1) is a pluripotent cytokine that promotes angiogenesis, tumor growth, and metastasis in experimental models; its presence in some human cancers is associated with aggressive tumor biology. The purpose of these studies was to characterize the role of IL-1 in human cancers and determine if inhibition of IL-1 via its receptor antagonist, IL-1Ra, alters tumor growth and metastatic potential," researchers in the United States report.
"IL-1 mRNA or protein levels were determined in clinical tumor samples, cancer cell lines, and xenografts using...
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