Medical Letter on the CDC and FDA

HIV/AIDS Pathogenesis - HIV Vif and Vpr play key roles in T cell death and cell cycle arrest

HIV/AIDS Testing - Calypte's Aware rapid HIV-1/2 tests receive approval in the Republic of Kenya

HIV/AIDS Therapy - HIV-infected newborns may need higher nelfinavir dose than FDA guidelines

HIV/AIDS Therapy - Integrase cofactor plays key role in HIV replication cycle

HIV/AIDS Therapy - U.S. FDA tentatively approves a co-package of generic AIDS drugs

HIV/AIDS Vaccines - Studies add new findings to HIV/AIDS vaccines body of knowledge

Heart Disease - Oral contraceptives increase stroke and heart attack risks in women with hypertension

Heart Failure - Nanogen receives U.S. FDA 510(k) clearance for StatusFirst congestive heart failure NT-proBNP Test

Hepatitis B Therapy - PowderMed's Therapeutic DNA vaccine for chronic hepatitis B enters phase I trials in patients

Hepatitis B Virus - Recombinant GB virus B hepatitis virus with a p7 protein developed

Hernia - Corgentech reports Phase 2 trial results in Europe for 4975 in hernia repair pain

Immunizations - Position paper on adolescent immunization has been released by Society for Adolescent Medicine

Immunology - HIV intrauterine exposure affects infants' cellular immune response

Influenza Vaccine - Inactivated influenza vaccine was not effective in children younger than 2

Influenza Vaccine - Influenza vaccination rates in British nursing homes vary widely

Influenza Vaccine - Universal influenza vaccine plus adjuvant provides complete protection

Influenza Vaccine - Virosomal influenza vaccine is effective in most HIV-infected children on HAART

Influenza Vaccines - Recent findings illuminate research in influenza vaccines

Information Technology - Maxant Technologies receives U.S. FDA clearance to market MediPort integrated digital workstations

Iron Deficiency - Ferrazone iron compound receives FDA acceptance

Listeriosis - Method for DNA probe detection of Listeria in culture is improved

Lung Cancer - Cytokinetics reports data for ispinesib in platinum-sensitive non-small cell lung cancer

Lyme Disease - Anti-IL-15 prevents arthritis in Borrelia-vaccinated and -infected mice

Lymphatic Filariasis - China to be officially designated free of lymphatic filariasis

Malaria Vaccine - Escheriosome-entrapped antigens protect against Plasmodium yoelii nigeriensis

Market Analysis - Dyslipidemia and other metabolic disorders are focus of latest offering

Marketing - Santarus announces U.S. launch of capsule form proton pump inhibitor for heartburn, GERD

Medical Devices - Analogic receives 510(k) U.S. FDA clearance for wide-beam fetal ultrasound transducer

Medical Devices - ArthroCare receives U.S. FDA clearance for vertebroplasty device

Medical Devices - BSD Medical applies for U.S. FDA approval of cancer treatment system

Medical Devices - Detectability decreases with off-normal viewing in liquid crystal displays

Medical Devices - MatrixOne and IntegWare enter alliance to deliver compliance solutions to medical device industry

Medical Devices - U.S. FDA approves Sorenson's release of ambulatory infusion pumps for pain management

Medical Errors - Method for automatic identification of confusable drug names is developed

Melioidosis Vaccine - DNA vaccine protects against Burkholderia pseudomallei infection

Meningitis Vaccine -  Haemophilus influenzae type b vaccination of children is focus of review

Mergers & Acquisitions - IRIS International acquires Leucadia, enters the molecular-diagnostics market

Muscular Dystrophy - PTC Therapeutics receives fast track designation for PTC124 for Duchenne muscular dystrophy

Mutagenesis - Mouse lymphoma thymidine kinase gene mutation assay is described

Myelodysplastic Syndromes - Pharmion Corporation submits Vidaza new drug application supplement for IV administration

Occupational Health - Lung disease risk is increased in workers at microwave popcorn plants

Ovarian Cancer - PABA/NO analogues with improved solubility and aqueous stability synthesized

Pelvic Inflammatory Disease - IUD increases risk of pelvic inflammatory disease among women with STD

Pigmented Lesions - Cynosure receives additional FDA clearance for pulse dye laser

Pneumococcal Vaccines - Reports advance knowledge in pneumococcal vaccines research

Polio Vaccine - No link was found between oral polio vaccine and intussusception

Polymerase Chain Reaction - DNA and RNA references for qRT-PCR assays in cervical cells are reported

Prion Disease - Data advance knowledge in prion disease research

Proteomics - Data advance knowledge in proteomics research

Restructuring - NitroMed restructures research and development operations to focus on extended release BiDil

SARS Vaccine - Inactivated Vero-cell SARS vaccine is safe and effective in monkeys

SARS Vaccine - SARS vaccine candidates were evaluated in mice challenged with SARS coronavirus

Sepsis - Masimo announces U.S. FDA clearance of Masimo Rainbow SET Rad-57cm

Sexual & Reproductive Health - New data indicate few young Americans tested for chlamydia

Sexual & Reproductive Health - Uterine leiomyomata may be increased in women with higher luteinizing hormone levels

Sexually Transmitted Disease - No clear link was found between hormonal contraceptives and STD risk

Smallpox Vaccines - New data illuminates research in smallpox vaccines

Smallpox Vaccines - Researchers provide details of new studies and findings in the area of smallpox vaccines

Thrombolysis - New anticoagulants are under development

Transplant Medicine - VCU medical center team implants first total artificial heart on East Coast

Trypanosomiasis Vaccine - DNA vaccine controls Trypanosoma cruzi infection

Tuberculosis Transmission - TB increase among young children caused by close family interaction and delayed diagnoses

Tuberculosis Vaccine - BCG substrains confer different levels of protection against Mycobacterium tuberculosis

Tuberculosis Vaccine - Dendritic cells infected with Mycobacterium tuberculosis mutants induce immunity

Tuberculosis Vaccine - Neonatal BCG immunization rate is low among white British children

Twin-to-Twin Transfusion Syndrome - U.S. FDA approves humanitarian device exemption for treatment of Twin-to-Twin Transfusion syndrome

Type 2 Diabetes - New drug application for Galvus as diabetes treatment accepted for review by U.S. FDA

Vaccine Vector - Adenoviral vector has limited toxicity after salivary gland delivery

Venous Thromboembolism - Hormonal contraceptive use by women with thrombogenic mutations is focus of review

Virology - Findings in virology provide new insights