HIV/AIDS Therapy
HIV-infected newborns may need higher nelfinavir dose than FDA guidelines
Published in Medical Letter on the CDC and FDA, April 26th, 2006
"As a relationship between nelfinavir antiretroviral efficacy and plasma concentrations has been previously established, nelfinavir pharmacokinetics" were evaluated in a recent study from France, "in order to optimize the individual treatment schedule in a pediatric population."
"A population pharmacokinetic model was developed to describe the concentration-time course of nelfinavir and its active metabolite M8," explained D. Hirt and coauthors working at Hôpital Saint Vincent de Paul in Paris. "Individual characteristics were used to explain the...
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