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Allergy Medicine

Method to determine phenylephrine, chlorpheniramine, and methscopolamine is developed

Published in Medical Letter on the CDC and FDA, April 26th, 2006

Investigators have developed a method for the determination of phenylephrine hydrochloride, chlorpheniramine maleate, and methscopolamine nitrate in tablets or capsules by liquid chromatography with two UV absorbance detectors in series.

"A procedure is presented for the simultaneous determination of phenylephrine HCl (PE), chlorpheniramine maleate (CM), and methscopolamine nitrate in commercial tablets or capsules by liquid chromatography (LC) with two UV absorbance detectors in series. Reference and sample solutions are prepared in methanol. LC separations are performed on a 7.5-cm Novapak silica column. The mobile phase was prepared by mixing 930 mL methanol with 70...

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