Susan Hasty, Publisher
Table of Contents . . . May 3rd, 2006
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Medical Letter on the CDC and FDA | Other Publications
Cancer Risk Factors - Wilms tumor is not linked to hazardous chemical exposure
Contraception - Progestogen-only contraceptives are safe for women with sickle cell anemia
Environmental Health - Oxidative metabolites of di(2-ethylhexyl) phthalate identified in humans
Helicobacter Pylori - Iron deficiency linked to Helicobacter pylori infection in Alaskan school children
Tuberculosis - Tuberculosis outbreak in childcare center in San Francisco is described
Acne - Survey suggests adults with acne scarring at a disadvantage at work and play
Allografts - Vascularized allograft rejection is induced by platelet-derived or soluble CD154
Anthrax Antitoxin - Anthrax toxin neutralized by chimpanzee monoclonal antibodies against protective antigen
Apoptosis - Epidermal growth factor receptor cleavage is independent of its internalization
Avian Influenza - Hemagglutination inhibition test detects human antibodies against avian influenza virus
Avian Influenza - Replicor's antiviral drug is active against H5N1 avian influenza
Bacterium - Researchers' data from Taiwan, Israel and Slovakia advance bacterium research
Bipolar Disorder - Anticonvulsants in the treatment of bipolar mania are the focus of review
Blood Glucose - Hypoguard receives 510(k) clearance to market Assure Pro Blood Glucose Monitoring System
Breast Cancer - Researchers' findings from the United States, Australia and Israel advance breast cancer research
Breast Implants - Mentor submits premarket approval application for Contour Profile gel breast implant products
Business & Finance - BioSante posts $0.50 per share loss
Business & Finance - DOR BioPharma reports year-end financials and accomplishments, early 2006 achievements
Business Update - Chicago research scientists launch Precision Biomarker Resources
Business Update - European Commission approves Genzyme's Myozyme
Business Update - Valera acquires rights to U.S. FDA-approved chemotherapeutic bladder cancer treatment
Business Update - Virginia Commonwealth heart center team implants temporary artificial heart
Cancer Gene Therapy - Prostate cancer is linked to aberrant methylation and deacetylation
Cancer Therapy - Enzon initiates clinical program for ONCASPAR, U.S. FDA completes review of IND
Cancer Vaccine - Immunotoxin LMB-2 selectively eliminates human regulatory T lymphocytes
Carcinogenesis - Carcinogen identification using in silico methods is examined
Carcinogenesis - Late-stage cancers and fibrotic diseases treated by Smad3 inhibitors
Carcinogenesis - Methods to identify carcinogens using surrogate endpoints have been examined
Cardiovascular Disease - Immuno-turbidimetric C-reactive protein assay is effective for heart risk estimation
Cell Biology - Researchers from the United States, United Kingdom and Switzerland describe findings in cell biology studies
Cervical Cancer - Cervarix, GSK's candidate vaccine for cervical cancer, demonstrates sustained efficacy
Chlamydia Vaccine - Vaccination against chlamydial infections of man and animals are focus of review
Chronic Fatigue Syndrome - Molecular profiling of chronic fatigue syndrome presents challenges
Chronic Pain - Once daily Ultram ER extended-release analgesic tablets now available in the U.S.
Clinical Trials - EpiCept announces publication of Phase III Ceplene study results for acute myeloid leukemia
Coccidioidomycosis - Researchers from the United States provide details of new studies and findings in the area of coccidioidomycosis
Contraception - Oral contraceptives increase stroke risk in women with migraine history
Contraception - Sterilization at younger age is more likely to cause regret
Crohn Disease - U.S. FDA grants priority review of REMICADE for treatment of pediatric Crohn disease
Dental Care - IsoTis gets U.S. FDA clearance for Accell Connexus and OrthoBlast II in dental indications
Dermatology - Topical ointment for treating psoriasis vulgaris in adults now available as prescription
Diabetes - Studies from the United States add new findings to diabetes body of knowledge
Diabetes Control - Study shows insulin glargine plus metformin effective for people with type 2 diabetes
Diabetes Therapy - Clinical practice recommendations are not being met in diabetic adults
Diagnostics - Method to test deviation for most probable numbers in a serial dilution test is presented
Diagnostics - Over-the-counter rapid HIV tests are on the horizon
Diagnostics - Svizera Labs to supply Designer Diagnostics' Test Kits to World Health Organization
Diarrhea - Dr. Reddy's launches 'Z & D', a zinc sulphate adjuvant for treating diarrhea
Diet & Nutrition - Preconceptional fasting of fathers alters serum glucose in offspring of mice
Drug Delivery - Ocular barriers to transscleral drug delivery are assessed in a rabbit model
Drug Development - Adams Respiratory initiates phase II trial of erdosteine for bronchitis
Drug Development - Astellas receives U.S. FDA approval of Prograf (tacrolimus) for heart transplant patients
Drug Development - Avanir's Neurodex NDA accepted by U.S. FDA with priority review
Drug Development - Barr's Duramed withdraws NDA for Lo Seasonale extended-cycle oral contraceptive
Drug Development - Bioniche receives U.S. FDA approval to proceed with phase III bladder cancer trials
Drug Development - Edison announces U.S. FDA grants EPI-A0001 orphan drug designation for mitochondrial disease
Drug Development - Gen-Probe submits amended regulatory application for PROCLEIX ULTRIO assay to U.S. FDA
Drug Development - Takeda files NDA for Actos and extended-release metformin combination product
Drug Development - U.S. FDA summarizes 2005 accomplishments on eve of 100th anniversary
Drug Safety - Duloxetine depression treatment safe and effective for African-American patients
Ebola - Studies from the United States and Canada describe new findings in ebola research
Encephalitis - New findings in encephalitis described from the United States, South Africa and Finland
Facilities - U.S. FDA grants approval to SpectraScience to make biopsy system in California facility
Finance - Cellegy reports net loss of just over $5 million
Finance - Chembio reports 19% increase in 2005 revenues
Food Allergy - ELISA for screening human antigen-specific IgE has been improved
Food Safety - U.S. National Cancer Institute study confirms safety of aspartame
Generic Drugs - Connetics files Citizen Petition for Soriatane with the U.S. FDA
Generic Drugs - IMPAX receives FDA approval for generic version of SALAGEN Tablets
Generic Drugs - Teva announces U.S. FDA approval of ANDA for generic Deferoxamine Mesylate for Injection
Geriatrics - Needle length needed for intramuscular injection in elderly is defined
Group B Streptococcus - Cepheid expands menu of CE IVD products available in Europe with introduction of Xpert GBS test
HIV/AIDS - New data from the United States and France lluminates research in HIV/AIDS
HIV/AIDS - New data from the United States lluminates research in HIV/AIDS
HIV/AIDS - Reports from the United States and Japan describe recent advances in HIV/AIDS research
HIV/AIDS - Reports from the United States and United Kingdom describe recent advances in HIV/AIDS research
HIV/AIDS Evolution - Persistent immune activation reduces its regenerative capacity and facilitates HIV evolution
HIV/AIDS HAART Interruption - HAART interruption blunts but does not abrogate CD4 cell responses to IL-2 therapy
HIV/AIDS Screening - Routine medical screening most frequent reason for HIV testing among adolescents
HIV/AIDS Therapy - Age-related effects on nelfinavir and M8 pharmacokinetics have been examined
HIV/AIDS Therapy - U.S. FDA tentatively approves a co-package of generic AIDS drugs
HIV/AIDS Vaccine - Polyvalent DNA prime/protein boost HIV-1 vaccine elicits cellular immune responses
Health Promotion - Pacific Health Summit deems "early health" the focus of strategic initiatives
Heart Disease - Reports from the United States and Switzerland describe recent advances in heart disease research
Hepatitis C Virus - Sensitivity of 2nd-generation enzyme immunoassay for hepatitis C decreased in cancer patients
Imaging - DOBI Medical International premieres ComfortScan System for breast imaging
Imaging - U.S. FDA grants 510(k) clearance for megavoltage cone beam imaging package
Infectious Trachoma - Infectious trachoma not eradicated after one mass azithromycin distribution
Influenza - CombiMatrix publishes influenza paper in collaboration with World Health Organization
Influenza - DNA vaccine with adjuvant protects mice against two human influenza strains, data show
Influenza - U.S. FDA approves use of Relenza for prevention of influenza
Influenza Vaccine - Fluarix-inactivated split-virus influenza vaccine is focus of review
Influenza Vaccine - Influenza vaccination is safe for heart transplant patients
Legal Issues - Cobalis settles outstanding litigation with Gryphon Master Fund, L.P.
Malaria - Reports from the United Kingdom and Denmark advance knowledge in malaria research
Malaria - Studies from Colombia and Australia advance knowledge in malaria research
Medical Devices - Boston Scientific receives U.S. FDA clearance for Super Sheath Introducer Sheath
Medical Devices - EncounterCare Solutions, Inc. announces U.S. FDA 510(K) approval of liquid oxygen gauge
Medical Devices - VeriChip recognized by Center for Devices and Radiological Health
Melioidosis Vaccine - Dendritic cell vaccine protects against Burkholderia pseudomallei
Meningitis - Data from Brazil, Poland and Sweden advance knowledge in meningitis research
Meningitis - National Haemophilus influenzae type B vaccine policy needed in Vietnam
Meningitis - Recommendations for managing bacterial meningitis in Qatar are presented
Meningitis - Risk and protective factors for meningococcal disease in adolescents are outlined
Meningococcal Vaccine - Meningococcal conjugate vaccine is safe and immunogenic in humans
Mergers & Acquisitions - EPIX and Predix announce merger agreement
Obesity Pathogenesis - Genetic variations related to obesity, insulin resistance, and cancer discussed
Occupational Health - Chronic beryllium disease in workers at copper-beryllium distribution centers is examined
Oncology - Studies from the United States, Italy and Wales advance knowledge in oncology research
Pancreatic Cancer - Pancreatic cancer NQO1 expression may have diagnostic/prognostic value
Pancreatic Cancer - Second primary pancreatic cancer risk factors identified
Pap Test - Effectiveness of liquid-based Pap test systems have been compared
Partner Violence - Interventions to prevent perpetration of partner violence are focus of review
Patents - ThermoGenesis notified of third patent allowance for autologous thrombin processing device
Pediatric Vaccine - Immunization coverage is low among young low-income children in Ontario
Pediatric Vaccine - Survival analysis is helpful in assessing delay in age-appropriate vaccination
Pediatrics - Siblings of infants with prenatal drug exposure receive poorer medical care
Pharmaceutical Research - Best Practices introduces benchmark study on pharma staffing and structure
Philanthropy - GM Fleet mobilizes CDC's global health force in Asia and Africa
Pneumococcal Vaccine - Pneumococcal parapneumonic empyema is more common since pneumococcal conjugate vaccine introduction
Pre-eclampsia - Pre-eclampsia severity, but not incidence, may be reduced with calcium supplementation
Professional Education - New U.S. FDA investigations operations manual available
Prostate Cancer - Cytogen submits IND for CYT-500 for treatment of metastatic hormone-refractory prostate cancer
Prostate Cancer - Reports from the United States, Netherlands and United Kingdom advance knowledge in prostate cancer research
Public Health - Public school immunization data were used to determine community immunization coverage
Public Health - Scrub typhus is endemic in Republic of Palau
Pulmonary Arterial Hypertension - First patient enrolled in CoTherix REVEAL Registry
Quality Assurance - MDS Inc. updates progress on U.S. FDA review of Montreal bioanalytical operations
Rabies Virus - Viral RNA in bloodstream suggests viremia occurs in ill rabies-infected mice
SARS - U.S. personnel in Korea are the largest U.S. military population at risk for SARS
SARS Outbreak - Hospital precautions during major acute SARS outbreak are outlined
Sexual & Reproductive Health - Enrollment begins for NIH-registered clinical study of Zestra Feminine Arousal Fluid
Sexual Abuse - Prevalence of sexual abuse is high among women in China
Skin Cancer - PhotoMedex enters alliance to develop and distribute skin cancer detection system
Skin Cancer Risk Factors - Sun protection education is low priority in U.S. secondary schools
Staphylococcus - Data from the United States advance knowledge in staphylococcus research
Transplant Medicine - U.S. FDA approves Prograf to prevent rejection of heart transplant
Tuberculosis - Large tuberculosis outbreak occurred in private-home family child care center
Tuberculosis - Mycobacterial antigens can distinguish between acute and latent TB
Tuberculosis - Studies from the United Arab Emirates and United States add new findings to tuberculosis body of knowledge
Tuberculosis Vaccine - ProPred analysis can identify antigens of Mycobacterium tuberculosis
Tuberculosis Vaccine - Vaccines and diagnostic reagents to control TB in cattle are focus of review
Urology - Urologix receives U.S. FDA approval to market new CoolWave control unit
Vaccine Adjuvant - Nasal CpG ODN vaccine protects against Haemophilus influenzae in nasopharynx
Vaccine Safety - Acetaminophen or ibuprofen do not prevent local reactions to fifth DTaP vaccination
Vaccine Safety - Tdap vaccine can be given safely 18 months after tetanus-diphtheria vaccination
Weight Loss - Hypothalamic rAAV-mediated GDNF gene delivery ameliorates age-related obesity
West Nile Virus - Birth outcomes after maternal West Nile Virus infection have been examined
Yellow Fever Vaccine - Yellow Fever vaccine activates dendritic cell subsets to stimulate polyvalent immunity
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