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Obesity Pathogenesis

Genetic variations related to obesity, insulin resistance, and cancer discussed

Published in Medical Letter on the CDC and FDA, May 3rd, 2006

Genetic polymorphisms associated with obesity, insulin resistance, and colorectal cancer are discussed.

"There is increasing evidence that dysregulation of energy homeostasis is associated with colorectal carcinogenesis. Epidemiological data have consistently demonstrated a positive relation between increased body size and colorectal malignancy, whereas mechanistic studies have sought to uncover obesity-related carcinogenic pathways," reviewers in the United States report.

M.J. Gunter and M.F. Leitzmann, U.S. National Cancer Institute summarized, "The phenomenon of 'insulin resistance' or file impaired ability to normalize plasma glucose levels has...

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