Virology
PKR activity is modulated in cells infected by bovine viral diarrhea virus
Published in Medical Letter on the CDC and FDA, May 10th, 2006
According to recent research published in the journal Virus Research, "Bovine viral diarrhea virus is an important animal pathogen. The cytopathic and noncytopathic biotypes of the virus are associated with distinct pathologic entities.
"A striking difference between the two biotypes is viral RNA accumulation in infected cells. Viral dsRNA is thought to activate the protein kinase regulated by RNA (PKR); an important mediator of innate immunity. In this study, we investigated PKR activation and its consequences in BVDV-infected...
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