Malaria Therapy
Mefloquine induces dose-related neurological effects in rat model
Published in Medical Letter on the CDC and FDA, May 10th, 2006
"Mefloquine is one of the drugs approved by the FDA for malaria chemoprophylaxis. Mefloquine is also approved for the treatment of malaria and is widely used for this purpose in combination with artesunate. However, the clinical utility of the compound has been compromised by reports of adverse neurological effects in some patients," noted scientists in the United States.
"In the present study, the potential neurological effects of mefloquine were investigated with six 7-week-old female rats given a single oral dose of the compound," said Geoffrey Dow and colleagues at the Walter...
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