Published in Medical Letter on the CDC and FDA, May 17th, 2006
Study 1: Scientists have achieved the stable growth of wild-type hepatitis A virus in cell culture.
"Human wild-type (wt) hepatitis A virus (HAV), the causative agent of acute hepatitis, barely grows in cell culture and in the process accumulates attenuating and cell culture-adapting mutations. This genetic instability of wt HAV in cell culture is a major roadblock to studying HAV pathogenesis and producing live vaccines that are not overly attenuated for humans. To develop a robust cell culture system capable of supporting the efficient growth of wt HAV, we...
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