Virology
Researchers from the United States, Germany and Japan publish new studies and findings in the area of virology
Published in Medical Letter on the CDC and FDA, May 17th, 2006
Study 1: Scientists have achieved the stable growth of wild-type hepatitis A virus in cell culture.
"Human wild-type (wt) hepatitis A virus (HAV), the causative agent of acute hepatitis, barely grows in cell culture and in the process accumulates attenuating and cell culture-adapting mutations. This genetic instability of wt HAV in cell culture is a major roadblock to studying HAV pathogenesis and producing live vaccines that are not overly attenuated for humans. To develop a robust cell culture system capable of supporting the efficient growth of wt HAV, we...
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