Tuberculosis Vaccine
Anti-mycobacterial Th1-cell responses does not enhance protection against tuberculosis
Published in Medical Letter on the CDC and FDA, May 24th, 2006
According to a study from France and the Czech Republic, "Bordetella pertussis adenylate cyclase (CyaA) toxoid is a powerful nonreplicative immunization vector targeting dendritic cells, which has already been used successfully in prophylactic and therapeutic vaccination in various preclinical animal models. Here, we investigated the potential of CyaA, harboring strong mycobacterial immunogens, i.e., the immunodominant regions of antigen 85A or the complete sequence of the 6-kDa early secreted antigenic target (ESAT-6)...
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