Cell Regulation

Nitric oxide gradients influence chemotaxis of endothelial cells

Published in Medical Letter on the CDC and FDA, May 24th, 2006

Recent research from the United States published in the journal Free Radical Biology and Medicine has reported on the guanylyl cyclase-dependent chemotaxis of endothelial cells in response to nitric oxide (NO) gradients.

"NO is an important regulator of angiogenesis and neovascularization. The nature of endothelial cell motility responses to NO was examined using a Boyden chamber method," wrote J.S. Isenberg and colleagues, U.S. National Cancer Institute.

"NO generated via decomposition of either DEA/NO or DETA/NO produced increases in human umbilical vein endothelial cell (HUVEC) chemotaxis, which were completely abrogated by ODQ, a soluble...

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Source: Medical Letter on the CDC and FDA (2006-05-24)

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