Genetics & Genomics
Gene expression profiling can predict quality of cell substrate
Published in Medical Letter on the CDC and FDA, June 7th, 2006
"Changes in cell culture conditions influence the metabolism of cells, which consequently affects the quality of the products that they produce, such as viral vectors, recombinant proteins, or vaccines. Currently there is no effective technique available to monitor global quality of cells in cell culture. We describe a new method using gene expression profiling by microarray to predict the quality of cell substrates. Human embryonic kidney 293 cells are a commonly used cell substrate in the production of biological products," scientists in the United States report.
"We demonstrate...
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