Polio Vaccine
Reversions in 5'-untranslated region of poliovirus after vaccination are analyzed
Published in Medical Letter on the CDC and FDA, June 21st, 2006
According to a study from the United States, "Replication of Sabin strains used in oral poliovirus vaccine (OPV) in the intestines of vaccine recipients leads to reversions that increase virus neurovirulence. Previously, a small study reported that prior immunization with inactivated poliovirus vaccine (IPV) resulted in faster accumulation of revertant virus, thus potentially increasing the risk of vaccine-associated...
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