Developmental Biology
Hindbrain development requires a threshold level of Gbx2
Published in Medical Letter on the CDC and FDA, July 2nd, 2006
"Gbx2 is a homeobox gene that plays a crucial role in positioning the mid/hindbrain organizer (isthmus), which regulates midbrain and cerebellar development primarily through the secreted factor FGF8. In Gbx2 null homozygotes, rhombomeres (r) 1-3 fail to develop and the isthmic expression of Fgf8 is reduced and disorganized.
"These mutants fail to form a cerebellum, as it is derived from r1. Here, we analyze mice homozygous for a Gbx2 hypomorphic allele (Gbx2(neo))," wrote S.T. Waters and colleagues, U.S. National Institutes of...
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