Dengue Fever

Data from Cuba, the United States and Brazil advance knowledge in dengue fever research

Published in Medical Letter on the CDC and FDA, July 16th, 2006

Dengue fever data are the focus of recent research from Cuba, the United States and Brazil.

Study 1: A recombinant fusion protein containing the domain III of the dengue-2 envelope protein is immunogenic and protective in nonhuman primates.

"We have previously reported the construction and evaluation in mice of recombinant fusion proteins formed by a fragment (aa 286-426) of the dengue envelope protein and the P64k protein from Neisseria meningitidis. In this work we describe the immunization of Macaca fascicularis monkeys with two variants of these proteins [PD3 (insertion variant) and PD5 (fusion variant)] corresponding to serotype...

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Source: Medical Letter on the CDC and FDA (2006-07-16)

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