Respiratory Syncytial Virus
Alpha and lambda interferon suppress CD4 T cells induced by respiratory syncytial virus
Published in Medical Letter on the CDC and FDA, July 23rd, 2006
Investigators writing in the Journal of Virology report, "The mechanism by which respiratory syncytial virus (RSV) suppresses T-cell proliferation to itself and other antigens is poorly understood. We used monocyte-derived dendritic cells (MDDC) and CD4 T cells and measured [3H]thymidine incorporation to determine the factors responsible for RSV-induced T-cell suppression."
"These two cell types were sufficient for RSV-induced suppression of T-cell proliferation in response to cytomegalovirus or Staphylococcus...
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