Alcohol Use
TLR2- and TLR4-mediated signals determine inflammation level caused by alcohol in monocytes
Published in Medical Letter on the CDC and FDA, August 13th, 2006
"Most pathogens express ligands for multiple TLRs that share common downstream signaling. In this study, we investigated the effects of acute alcohol on inflammatory pathways induced by TLR2 or TLR4 ligands and their combination," scientists writing in the Journal of Immunology report.
"In human monocytes, alcohol attenuated TLR4- but not TLR2-induced TNF-alpha protein and mRNA levels and NF-kappa B activation," said Shilpa Oak and colleagues at the University of Massachusetts. "In contrast, acute alcohol augmented TNF-a...
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