Malaria
Findings from the United States and Colombia describe new data in malaria research
Published in Medical Letter on the CDC and FDA, August 13th, 2006
Study 1: The FC gamma receptor IIA (CD32) polymorphism is associated with malarial anemia and high-density parasitemia in infants and young children.
"Protective immunity against Plasmodium falciparum is partially mediated through binding of malaria-specific IgG antibodies to Fc gamma receptors. Polymorphic variability in Fc gamma RIIa (H/R-131) is associated with differential binding of IgG subtypes and malaria disease outcomes. However, the role of Fc gamma RIIa-131 variability in conditioning susceptibility to severe malarial anemia, the primary manifestation...
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